HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-fluorobenzene → methyl 8-[(2R)-(1-(4-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | methyl 2-morpholino-4-oxo-8-[(2R)-pyrrolidin-2-yl]chromene-6-carboxylate | HCID 86672411 | — |
| Product | methyl 8-[(2R)-(1-(4-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate | HCID 86672433 | 15% |
Reaction Steps
Methyl 2-morpholino-4-oxo-8-[(2R)-pyrrolidin-2-yl]chromene-6-carboxylate (130 mg, 0.36 mmol) was reacted with 1-bromo-4-fluorobenzene (0.239 ml, 2.18 mmol) to afford methyl 8-[(2R)-(1-(4-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate (enantiomer 2, 24 mg, 15%) as a beige solid. Mass Spectrum: m/z [M+H]+=453.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530470B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-d7eb541d698149f8961e513e82cfcd62 |
| Source note | uspto-grants-2013_09 |