Sulfuric Acid → HCID 18536020, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Step A (2.07 g, 5.72 mmol) in 20 mL of ethanol was added stannous(II) chloride (4.32 g, 22.8 mmol). The solution was heated to 50° C. for 45 minutes hour, then cooled to room temperature. The solution was poured into 2 mL of concentrated sulfuric acid, then heated to 90° C. for 30 minutes. After cooling, the solution was concentrated in vacuo, basified with 20% NaOH solution, and extracted with EtOAc. The organic layer was washed with water and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the titled product as a brown oil.

Provenance & Evidence