Ethyl Acetate → HCID 18536035, compound

Participants

Reaction Steps

To a solution of N-tert-Butyloxycarbonylpiperazine (9.80 g, 52.6 mmol) and 3-(hydroxyphenyl)acetic acid (8.16 g, 152 mmol) in 100 mL of dimethylformamide at 0° C. was added 1-hydroxybenzotriazole hydrate (9.94 g, 73.6 mmol) and 1-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (13.06 g, 68.3 mmol). The solution was allowed to warm to room temperature. After 30 minutes, the reaction was poured into EtOAc and washed with water, saturated NH4Cl solution, saturated NaHCO3 solution, and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The product was isolated as a white foam which was used without further purification.

Provenance & Evidence