Sodium borohydride → HCID 178432785, compound

Participants

Reaction Steps

To a solution of the allyl ether from Step E (89.6 mg, 0.189 mmol) in 2 mL of tetrahydrofuran was added tetrakis(triphenylphosphine)palladium (4.3 mg, 0.0037 mmol). After 5 minutes, sodium borohydride was added (10.7 mg, 0.283 mmol), and the reaction was stirred at room temperature for 30 minutes. The reaction was quenched with saturated NH4Cl solution, then partitioned between EtOAc and saturated NaHCO3 solution. The organic layer was washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the desired product as a yellow foam.

Provenance & Evidence