Triethylamine → HCID 18536042, compound

Participants

Reaction Steps

To a solution of the product from Step E (426 mg, 1.19 mmol) in 5 mL of DMF at 0° C. was added triethylamine (0.532 mL, 3.82 mmol), followed by methanesulfonyl chloride (0.212 mL, 2.73 mmol). The reaction was stirred at room temperature overnight, then partitioned between EtOAc and 50% NaHCO3 solution. The organic layer was washed with water and brine, dried (MgSO4), filtered, and concentrated in vacuo. The product was isolated as a yellow gum which was used without further purification.

Provenance & Evidence