1-Hydroxybenzotriazole → HCID 18536164, compound

Participants

Reaction Steps

The product from Step D (66.1 mg, 0.156 mmol), 7-triisopropylsilyloxy-1-naphthoic acid from Step F (53.8 mg, 0.156 mmol), EDC hydrochloride (33.0 mg, 0.172 mmol), HOBT (23.2 mg, 0.172 mmol), and N,N-diisopropylethylamine (0.136 mL, 0.781 mmol) were stirred in dry, degassed DMF (0.5 mL) at 20° C. overnight. The reaction was stirred overnight and then injected onto a C18 preparative HPLC column and purified with a mixed gradient of 5%-95% acetonitrile/0.1% TFA; 95%-5%/0.1% aqueous TFA over 15 min. The title compound was isolated after conversion to the free base.

Provenance & Evidence