Sodium Hydroxide → 2-Ethyl-7-(2-methyl-4,5-diphenyl-imidazol-1-yl)-heptanoic acid

HRID 412208Notes

Reaction equation

HRID 412208 reaction equation
C([O:3][C:4](=[O:32])[CH:5]([CH:29](C)[CH3:30])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:14]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:13]=[C:12]1[CH3:28])C.[OH-].[Na+]>CO>[CH2:29]([CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:14]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:13]=[C:12]1[CH3:28])[C:4]([OH:32])=[O:3])[CH3:30]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 251904732-Isopropyl-7-(2-methyl-4,5-diphenyl-imidazol-1-yl)-heptanoic acid ethyl ester

Product 1

HCID 185375282-Ethyl-7-(2-methyl-4,5-diphenyl-imidazol-1-yl)-heptanoic acidYield 65.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(Scheme 3 (P)) This compound was obtained using the procedures as described above. The following scales and reagents were used: 2-Isopropyl-7-(2-methyl-4,5-diphenyl-imidazol-1-yl)-heptanoic acid ethyl ester (80 mg, 0.18 mmole), Sodium hydroxide (2N, 0.5 mL, 1.0 mmole), Methanol (5 mL). Product was obtained as white solid (46 mg, 64%). Mass Spec: 405.37 (MH+).

Sources & evidence

ORD record
ord-3930754fb7504a1ca8a686c6328dcaf4
Source dataset
uspto-grants-2003_05
Patent number
US06562846B2

Reaction notes

Loading…