Triethylamine → HCID 9916255, compound

Participants

Reaction Steps

A reaction was conducted by a similar procedure to that described in Example 52 using triethylamine (0.49 ml), nicotinoyl chloride hydrochloride (195 mg), 5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride (400 mg) and anhydrous N,N-dimethylformamide (8 ml). The reaction mixture was concentrated under reduced pressure. To the residue was added ethyl acetate and water. The precipitate was isolated by filtration to afford the title compound (297 mg, pale yellow powder, mp 213-215° C.).

Provenance & Evidence