Triethylamine → HCID 18537619, compound

Participants

Reaction Steps

A reaction was conducted by a similar procedure to that described in Example 52 using triethylamine (0.32 ml), 2,4-difluorobenzoyl chloride (0.10 ml), 5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride (400 mg) and anhydrous N,N-dimethylformamide (8 ml). The reaction mixture was concentrated under reduced pressure and partitioned between ethyl acetate and water. The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on a silica gel column using ethyl acetate:n-hexane=3:1 to afford the title compound (251 mg, white powder, mp 172-174° C.).

Provenance & Evidence