Pyridine → HCID 69663720, compound

HRID 412502Notes

Reaction equation

HRID 412502 reaction equation
[N:1]1C=CC=[CH:3][CH:2]=1.[C:7]([O:10][C:11](=[O:13])C)(=[O:9])[CH3:8]>C(Cl)Cl>[C:2]([NH2:1])(=[O:9])[CH3:3].[O:10]1[CH2:7][CH2:8][NH:1][C:11]1=[O:13]

Participants

4

Reactant 2

HCID 1049PyridineHCID 7918Acetic Anhydride

Product 1

HCID 69663720HCID 69663720, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetylation of Oxazolidinone Amine. To the crude oxazolidinone amine residue 16a in DCM at room temperature was added pyridine (30 equivalents) and acetic anhydride (20 equivalents). The solution was stirred for 2 hrs and concentrated in vacuo, The oxazolidinone acetamide residue was purified by HPLC to provide pure oxazolidinone acetamide.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe oxazolidinone acetamide residue was purified by HPLC

Sources & evidence

ORD record
ord-dc719349305e4d1cb2e6da7d478ece3d
Source dataset
uspto-grants-2003_05
Patent number
US06562844B2

Reaction notes

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