Benzoyl chloride → 7-[1-(Pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide

Temperature

75 °C

To a solution of ammonium isothiocyanate (220 mg) in acetone (4.5 ml) was dropwise added benzoyl chloride (0.32 ml) at room temperature, and the mixture was stirred at 75° C. for 10 min. Then, a mixture of 7-[1-(pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline (850 mg) in acetone (4.5 ml) and methylene chloride (4.5 ml) was added dropwise, and the mixture was stirred at the same temperature for 1 hour. After completion of the reaction, the solvent was evaporated and water was added. The mixture was extracted with chloroform. The organic layer was washed successively with water and saturated brine and dried over anhydrous sodium sulfate, and the solvent was evaporated. To the obtained residue was added conc. hydrochloric acid (10 ml), and the mixture was stirred under reflux for 1 hour. After completion of the reaction, water was added and the mixture was washed successively with ethyl acetate and chloroform. The aqueous layer was concentrated and the resultant residue was dissolved in water and ethanol, and neutralized with ion-exchange resin (IRA-410). This was filtrated and the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (chloroform:methanol=100:1-20:1) and dried under reduced pressure to give the title compound (450 mg).

1. customat room temperature
2. additionwas added dropwise
3. stirringthe mixture was stirred at the same temperature for 1 hour
4. customAfter completion of the reaction
5. customthe solvent was evaporated
6. additionwater was added
7. extractionThe mixture was extracted with chloroform
8. washThe organic layer was washed successively with water and saturated brine
9. dry with materialdried over anhydrous sodium sulfate
10. customthe solvent was evaporated
11. additionTo the obtained residue was added conc. hydrochloric acid (10 ml)
12. stirringthe mixture was stirred
13. temperatureunder reflux for 1 hour
14. customAfter completion of the reaction, water
15. additionwas added
16. washthe mixture was washed successively with ethyl acetate and chloroform
17. concentrationThe aqueous layer was concentrated
18. dissolutionthe resultant residue was dissolved in water
19. filtrationThis was filtrated
20. concentrationthe filtrate was concentrated
21. customThe obtained residue was purified by silica gel column chromatography (chloroform:methanol=100:1-20:1)
22. customdried under reduced pressure

ORD record

ord-0214daebda06404b81258dbf5b9f6c6a

Source dataset

uspto-grants-2003_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06562828B1