反应详情

温度

60 °C

7-[1-(Pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide (200 mg) was treated with hydrogen chloride—ethanol solution. To a suspension of the obtained residue in methanol (6 ml) was added methyl iodide (0.1 ml), and the mixture was stirred at 60° C. for 2 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was dissolved in water and ethanol and neutralized with ion-exchange resin (IRA-410). This was filtrated and the filtrate was concentrated and dried under reduced pressure to give the title compound (200 mg).

1. customAfter completion of the reaction
2. customthe solvent was evaporated
3. dissolutionthe obtained residue was dissolved in water
4. filtrationThis was filtrated
5. concentrationthe filtrate was concentrated
6. customdried under reduced pressure