反应详情

To a solution of 7-methylthiomethoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester (9.6 g) in methylene chloride (100 ml) was added a solution of sulfuryl chloride (2.75 ml) in methylene chloride (30 ml) under an argon atmosphere and with ice-cooling, and the mixture was stirred at the same temperature for 1 hour. The solvent was evaporated and toluene was added to the obtained residue to filter off insoluble material. The solvent was evaporated and dried under reduced pressure to give the title compound (7.4 g).

1. temperaturewith ice-cooling
2. customThe solvent was evaporated
3. additiontoluene was added to the obtained residue
4. filtrationto filter off insoluble material
5. customThe solvent was evaporated
6. customdried under reduced pressure