反应详情

4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid dihydrochloride (11 g) was dissolved in water (100 ml) and filtrated. 4N Aqueous sodium hydroxide solution (20 ml) was added dropwise at 50° C., and the mixture was stirred at the same temperature for 30 min. After completion of the reaction, the resultant solid was collected by filtration, washed successively with water and ethanol, and dried under reduced pressure to give the title compound (7.7 g).

1. filtrationfiltrated
2. addition4N Aqueous sodium hydroxide solution (20 ml) was added dropwise at 50° C.
3. customAfter completion of the reaction
4. filtrationthe resultant solid was collected by filtration
5. washwashed successively with water and ethanol
6. customdried under reduced pressure