2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 69695908, compound

Participants

Reaction Steps

To a solution of N-(2-amino-4-cyanophenyl)glycine tert-butyl ester (21.53 g) and N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid (42.18 g) in chloroform (300 ml) was added 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (23.68 g), and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:3) to give the title compound (44.479 g).

Provenance & Evidence