反应详情

A solution of 4-(2-hydroxyethylamino)-3-nitrobenzonitrile (3.11 g) and tin chloride dihydrate (16.94 g) in ethanol (50 ml) was stirred at 70° C. for 1 hour. After completion of the reaction, the solvent was evaporated and to the obtained residue were added tetrahydrofuran and 15% aqueous sodium hydroxide solution. The mixture was stirred and insoluble material and the aqueous layer were removed. The obtained organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated. The obtained solid was washed with chloroform, filtrated and dried under reduced pressure to give the title compound (2.08 g).

1. customAfter completion of the reaction
2. customthe solvent was evaporated and to the obtained residue
3. additionwere added tetrahydrofuran and 15% aqueous sodium hydroxide solution
4. custominsoluble material and the aqueous layer were removed
5. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. washThe obtained solid was washed with chloroform
8. filtrationfiltrated
9. customdried under reduced pressure