Sodium Bicarbonate → HCID 18536391, compound

Participants

Reaction Steps

To a solution of 2-[4-(pyrrolidin-3-yloxy)phenoxymethyl]-1-(2-methoxyethyl)benzimidazole-5-carboxamidine dihydrochloride (44 mg) in a mixture of tetrahydrofuran (2 ml) and water (0.6 ml) were added sodium hydrogencarbonate (38 mg), and ethyl acetoimidate hydrochloride (33 mg), and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, insoluble material was removed and the solvent was evaporated. The obtained residue was separated by HPLC (50% methanol-water, 0.05% trifluoroacetic acid). To the obtained residue was added dil. hydrochloric acid and the solvent was evaporated and dried under reduced pressure to give the title compound (40 mg).

Provenance & Evidence