反应详情

To a soution of 7-[1-(3-formylpyridin-4-yl)piperidin4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester (50 mg) in a mixture of chloroform (0.5 ml) and methanol (0.2 ml) were added sodium cyanide (8 mg), manganese dioxide (250 mg) and acetic acid (0.003 ml), and the mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was filtrated and the solvent was evaporated. The obtained residue was purified by preparative thin layer chromatography (chloroform:methanol=15:1) and dried under reduced pressure to give the title compound (50 mg).

1. customAfter completion of the reaction
2. filtrationthe reaction mixture was filtrated
3. customthe solvent was evaporated
4. customThe obtained residue was purified by preparative thin layer chromatography (chloroform:methanol=15:1)
5. customdried under reduced pressure