Hydrochloric Acid → HCID 11237020, compound

Participants

Reaction Steps

To a solution of 4-[4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-yl]pyridine-3-carboxylic acid methyl ester dihydrochloride (43 mg) in methanol (0.2 ml) was added 1N aqueous sodium hydroxide solution (0.1 ml), and the mixture was stirred under reflux for 3 hours. After completion of the reaction, the reaction mixture was neutralized with 1N-hydrochloric acid and the solvent was evaporated. The obtained residue was purified by reverse phase preparative thin layer chromatography (40% aqueous acetonitrile, 1% trifluoroacetic acid) and the obtained residue was treated with hydrogen chloride-ethanol solution and dried under reduced pressure to give the title compound (15 mg).

Provenance & Evidence