HCID 18536432, compound → HCID 18536316, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(4-cyano-2-phenoxyacetamidophenyl)glycine tert-butyl ester (6.61 g) in acetic acid (250 ml) was stirred at 80° C. for 12 hours. After completion of the reaction, the solvent was evaporated and to the obtained residue was added trifluoroacetic acid (60 ml), and the mixture was stirred at 50° C. for 30 min. After completion of the reaction, the solvent was evaporated. To the obtained residue were added chloroform and acetone and the resultant solid was collected by filtration and dried under reduced pressure to give the title compound (5.0 g).

Provenance & Evidence