Hydrochloric Acid → HCID 60064202, compound

Participants

Reaction Steps

4-Ethoxycarbonyl-4-[2-(1,3-dioxolan-2-yl)ethyl]piperidine-1-carboxylic acid benzyl ester (460 mg) was dissolved in tetrahydrofuran (5 ml) and thereto was dropwise added conc. hydrochloric acid (5 ml) with ice-cooling, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was poured into aqueous sodium hydrogencarbonate solution and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated and the obtained residue was purified by silica gel column chromatography (hexane:acetone=5:1) to give the title compound (300 mg).

Provenance & Evidence