HCID 69697079, compound → HCID 69697996, compound

Participants

Reaction Steps

A solution of 4-[2-[5-cyano-2-(cyclohexylcarbamoylmethylamino)-phenylcarbamoyl]ethyl]-4-ethoxycarbonylpiperidine-1-carboxylic acid benzyl ester (300 mg) in acetic acid (10 ml) was stirred at 100° C. for 24 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate and washed with aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:3) and dried under reduced pressure to give the title compound (200 mg).

Provenance & Evidence