反应详情

A solution of 4-(4-aminophenoxy)piperidine-1-carboxylic acid tert-butyl ester (8.21 g), 2-chloromethyl-1-(cyclohexylcarbamoylmethyl)-5-cyanobenzimidazole (9.29 g) and diisopropylethylamine (9.8 ml) in dimethylformamide (93 ml) was stirred at 60° C. for 14 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was extracted with ethyl acetate and washed with water. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated. To the obtained residue were added ethyl acetate and hexane and the precipitated solid was collected by filtration, washed with diisopropyl ether and dried under reduced pressure to give the title compound (15.726 g).

1. customAfter completion of the reaction
2. customthe solvent was evaporated
3. extractionthe obtained residue was extracted with ethyl acetate
4. washwashed with water
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. additionTo the obtained residue were added ethyl acetate and hexane
8. filtrationthe precipitated solid was collected by filtration
9. washwashed with diisopropyl ether
10. customdried under reduced pressure