Benzyl Bromide → Ammonia

Participants

Reaction Steps

The title compound was prepared by a similar method to Example 6 from (2S)-1-(1,3-benzoxazol-2-yl)-N2-(4-piperidinyl)-2-piperidinecarboxamide [see Example 31] and benzyl bromide. The crude product was purified by column chromatography on silica gel eluting with a solvent system of 93:7:1, by volume, dichloromethane:methanol:0.88 aqueous ammonia solution to afford (2S)-1-(1,3-benzoxazol-2-yl)-N2-(1-benzyl-4-piperidinyl)-2-piperidinecarboxamide as an oil.

Provenance & Evidence