HRID412698

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18537929

未命名化合物

结构：CCOC(=O)Cc1nc2cc(CN3C(=O)c4ccccc4C3=O)ccc2[nH]1

HCID178470771

未命名化合物

PRODUCTS

生成物

结构：O=C1c2ccccc2C(=O)N1Cc1ccc2nc(Cc3nc4cc(OCCCCc5ccccc5)ccc4[nH]3)[nH]c2c1

HCID178514964

未命名化合物

收率 76.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

CONDITIONS

反应条件

温度: 185 °C

PROCEDURE

实验过程

A mixture of 5-(4-phenylbutoxy)benzene-1,2-diamine (0.06 g, 0.234 mmol) and ethyl 5-(1,3-dioxo-1,3-dihydroisoindol-2-ylmethyl)-1H-benzoimidazol-2-ylacetate (0.1 g, 0.234 mmol) was heated 1 hour at 185° C. under nitrogen. The mixture was suspended in diethyl ether, stirred vigorously for 1 hour. The solids were collected by filtration, washed with diethyl ether and dried to provide 2-{2-[5-(4-phenylbutoxy)-1H-benzoimidazol-2-ylmethyl]-3H-benzoimidazol-5-ylmethyl}isoindole-1,3-dione (0.1 g, 0.18 mmol).

WORKUP

后处理

filtrationThe solids were collected by filtration
washwashed with diethyl ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce3626b06ba14542bb94eafb328be406
来源数据集: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06562854B2
来源说明: uspto-grants-2003_05

反应 SMILES

[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[C:16]([NH2:18])[C:15]([NH2:19])=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:20]=[C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23](=[O:30])[N:22]1[CH2:31][C:32]1[CH:46]=[CH:45][C:35]2[NH:36][C:37]([CH2:39][C:40](OCC)=O)=[N:38][C:34]=2[CH:33]=1>C(OCC)C>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]3[NH:19][C:40]([CH2:39][C:37]4[NH:38][C:34]5[CH:33]=[C:32]([CH2:31][N:22]6[C:23](=[O:30])[C:24]7[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=7)[C:21]6=[O:20])[CH:46]=[CH:45][C:35]=5[N:36]=4)=[N:18][C:16]=3[CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1