Tetrahydrofuran → HCID 178479388, compound

Participants

Reaction Steps

A mixture comprising N-(4-amino-3-nitrophenyl)guanidine hydrochloride (12.0 g, 51.8 mmol), 10% palladium on carbon (1.0 g), tetrahydrofuran (100 mL) and methanol (100 mL) was hydrogenated at one atmosphere, filtered and concentration in vacuo to provide N-(3,4-diaminophenyl)guanidine hydrochloride (10.3 g, 98% yield) as a dark solid; 1H-NMR (300 MHz, DMSO-d6): 9.4 (s), 7.2 (s), 6.5 (d), 6.3 (s), 6.2 (d), 4.7 (s).

Provenance & Evidence