Tetrahydrofuran → HCID 178437535, compound

Participants

Reaction Steps

A mixture comprising benzyl 2-[1-(5-guanidino-1H-benzoimidazol-2-yl)ethyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-5-carboxylate (1.0 g, 2.2 mmol), 10% palladium on carbon (0.5 g), tetrahydrofuran (50 mL) and methanol (50 mL) was hydrogenated at one atmosphere, filtered and concentrated in vacuo to provide N-{2-[1-(4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-2-yl)ethyl]-1H-benzoimidazol-5-yl)-guanidine (0.69 g, 97% yield); LRMS(ESI): Calculated for C16H20N8: 324.4; Found (MH+): 325.2.

Provenance & Evidence