HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,5-Trifluoro-6-nitroaniline → 3,4,6-Trifluorobenzene-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,5-Trifluoro-6-nitroaniline | HCID 223085 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,4,6-Trifluorobenzene-1,2-diamine | HCID 595624 | 87% |
Reaction Steps
A mixture of 2,3,5-trifluoro-6-nitroaniline (300 mg, 1.56 mmol) and 10% palladium on carbon in absolute ethanol was hydrogenated overnight at atmospheric pressure, filtered under nitrogen and concentrated to provide 1,2-diamino-3,4,6-trifluorobenzene (219 mg, 87% yield) as a purple crystalline solid; MS M+ 162.7, +41. +82 (+ACN, +2ACN). (calcd for C6H5F3N2: 162.11).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562854B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-5495ef3acb214113a133c8fbd43a5744 |
| Source note | uspto-grants-2003_05 |