反应详情

A mixture of 46 g of dimethylmaleic acid anhydride, 48 g of 2-amino-2,3-dimethylbutyric acid amide and 70 ml of methylene chloride was heated at its boiling point for 15 minutes. After some of the solvent had been distilled off, the residual mixture was stirred with 300 ml of diethyl ether, and the product precipitated thereby was suction-filtered off. The desired compound (II) (90 g; 96%) was isolated as a crystalline solid, melting point 70°-72° C.

1. temperaturewas heated at its boiling point for 15 minutes
2. distillationAfter some of the solvent had been distilled off
3. customthe product precipitated
4. filtrationthereby was suction-filtered off