HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoanisole → HCID 11448114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoanisole | HCID 11358 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11448114 | HCID 11448114 | 97.6% |
Reaction Steps
2-Bromoanisole (98 mg, 0.52 mmol) reacted with 4-trifluoromethylphenylboronic acid (145 mg, 0.76 mmol) using 1 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and KF (90 mg, 1.55 mmol) in THF at room temperature for 3 h to give the title compound (128 mg, 97%). 1H-NMR (300 MHz, CDCl3): δ 13C{1H}-NMR (100 MHz, CDCl3): δ. GC/MS(EI): m/z (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562989B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-8a03704e06974ec0aec25dacc6e6d3ae |
| Source note | uspto-grants-2003_05 |