Potassium Phosphate, Tribasic → 2-methyl-4'-tert-butylbiphenyl

Participants

Reaction Steps

4-tert-butylbromobenzene (220 mg, 1.03 mmol) reacted with 2-methylphenylboronic acid (178 mg, 1.31 mmol) using 1 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and K3PO4 (424 mg, mmol) in toluene at 80° C. to give the title compound (223 mg, 97%) as a colorless oil: 1H-NMR (300 MHz, CDCl3): δ 7.49 (d, 2H, J=8.4 Hz), 7.34-7.30 (m, 6H), 2.36 (s, 3H), 1.44 (s, 9H). 13C{1H}-NMR (125 MHz, CDCl3): δ 149.50, 141.79, 138.88, 135.42, 130.26, 129.88, 128.81, 127.00, 125.69, 124.92, 34.51, 31.42, 20.58. GC/MS(EI): m/z (M+). Anal. Calcd for C17H20: C, 91.01; H, 8.99. Found: C, 90.72; H, 8.88.

Provenance & Evidence