HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorobenzene → Biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Biphenyl | HCID 7095 | 96% |
Reaction Steps
Chlorobenzene (56 mg, 0.50 mmol) reacted with phenylboronic acid (92 mg, 0.75 mmol) using 0.5/1.0 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and KF (87 mg, 1.50 mmol) in THF solvent at 45° C. to give the title compound (74 mg, 96%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562989B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-11a28f8228874516a4baf4c086c9cdc5 |
| Source note | uspto-grants-2003_05 |