Dimethylformamide → HCID 54511176, compound

Participants

Reaction Steps

Under nitrogen gas atmosphere and ice cooling, benzyl bromide (11.4 ml, 95.5 mmol) was added to a mixture of 60% sodium hydride (3.8 g, 95.5 mmol), Compound 11 (6.7 g, 19.1 mmol) and dimethylformamide (20 ml), and the mixture was stirred for 18 hours. Methanol was added to the reaction mixture under ice cooling and stirred for 1 hour, and the solvent was evaporated under reduced pressure. The residue was diluted with diethyl ether, washed successively with water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=10:1-9:1) to obtain Compound 12 (9.1 g, 90%).

Provenance & Evidence