Pyridine → HCID 53823170, compound

HRID 412863Notes

Reaction equation

HRID 412863 reaction equation
[CH2:1]([O:8][C@@H:9]1[C@@H:23]([OH:24])[C@@H:22]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C@@H:21]([CH2:33][O:34][C:35](=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37])[O:20][C@H:10]1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:47](OC(=O)C)(=[O:49])[CH3:48]>C1(C)C=CC=CC=1>[C:47]([O:24][C@H:23]1[C@@H:22]([O:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C@@H:21]([CH2:33][O:34][C:35](=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37])[O:20][C@@H:10]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[C@@H:9]1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:49])[CH3:48]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 54382137HCID 54382137, compound

Product 1

HCID 53823170HCID 53823170, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Compound 17 (10 mg, 18.0 μmol) was dissolved by addition of pyridine (1 mL). Acetic anhydride (0.5 mL) was added to the solution, and the mixture was stirred at the room temperature for 2 hours. The solvent was subjected to azeotropy with toluene, and the residue was purified with Sephadex LH-20 (CHCl3:MeOH=1:2) to obtain Compound 18 (11 mg, qu.).

Workup

  1. customthe residue was purified with Sephadex

Sources & evidence

ORD record
ord-8e8eb087e76649f787d791fdfdfc2ae9
Source dataset
uspto-grants-2003_05
Patent number
US06562954B1

Reaction notes

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