HCID 131723892, compound → HCID 131723890, compound

Participants

Reaction Steps

Compound 21 (170 mg, 0.160 mmol) was dissolved in a mixture of methanol and water (3:1, 15 mL) and palladium hydroxide/carbon (180 mg) was added thereto. Inside of the reaction system was replaced with hydrogen gas, and catalytic reduction was performed at room temperature for 4 hours. The reaction mixture was filtered through Celite, and the filtrate was evaporated. The residue was purified with a column of Sephadex LH-20 (CHCl3:MeOH:H2O=5:10:3), further purified with a column of Dowex-50 (Na+) type (CHCl3:MeOH:H2O=1:3:1), and finally purified with a column of Sephadex LH-20 (CHCl3:MeOH:H2O=5:10:3) again to obtain Compound 22 (101.4 mg, 90.6%).

Provenance & Evidence