Pivaloyl chloride → HCID 86758967, compound

Participants

Reaction Conditions

Reaction Steps

Compound 26 (647 mg, 0.885 mmol) was dissolved in pyridine (13 mL). To the solution, pivaloyl chloride (138 μl, 1.15 mmol) was added, and the mixture was stirred at −5 to 0° C. for 0.5 hour. Pivaloyl chloride (138 μl, 1.15 mmol) was further added thereto, and the mixture was stirred at −5 to 0° C. for 1 hour. The reaction mixture was diluted with ethyl acetate, and filtered through Celite, and the filtrate was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine. The ethyl acetate layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (toluene:AcOEt=10:1) to obtain Compound 27 (663 mg, 91.9%).

Provenance & Evidence