HCID 86758971, compound → HCID 86758970, compound

Participants

Reaction Steps

Compound 30 (230 mg, 0.209 mmol) was dissolved in a mixture of methanol, water and ethyl acetate (4:1:1, 25 mL), and palladium hydroxide/carbon (230 mg) was added thereto. Inside of the reaction system was replaced with hydrogen gas, and catalytic reduction was performed at room temperature for 20 hours. The reaction mixture was filtered through Celite, and the filtrate was evaporated. The residue was purified with a column of Sephadex LH-20 (CHCl3:MeOH=1:1) to obtain Compound 33 (126.1 mg, 81.5%).

Provenance & Evidence