HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → tert-Butyl 4-[(pyridin-4-yl)sulfanyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | pyridine-4-thiol | HCID 178418431 | — |
| Product | tert-Butyl 4-[(pyridin-4-yl)sulfanyl]piperidine-1-carboxylate | HCID 18538498 | — |
Reaction Steps
By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with 4-mercaptopyridine (0.67 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (1.33 g, 90%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562978B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-a8c065adc1604372b2b2180fd1b7aee2 |
| Source note | uspto-grants-2003_05 |