Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 18538940, compound

HRID 412889Notes

Reaction equation

HRID 412889 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[SH:15][C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:15][C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 178480602HCID 178480602, compound

Product 1

HCID 18538940HCID 18538940, compound

Procedure

By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with 2-mercapto-1-methylimidazole (0.68 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (1.04 g, 70%).

Sources & evidence

ORD record
ord-e35012947f01467e9527dfc8d9f7eb0e
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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