HCID 3013671, compound → HCID 3013672, compound

HRID 412926Notes

Reaction equation

HRID 412926 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]([N:19]([CH2:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][CH:32]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:31][CH2:30]2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[C].[Pd]>[CH2:35]([CH:32]1[CH2:33][CH2:34][N:29]([CH2:28][CH2:27][CH2:26][N:19]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[O:18])[CH2:30][CH2:31]1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 1

HCID 3013671HCID 3013671, compound

Product 1

HCID 3013672HCID 3013672, compoundYield 97.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The compound obtained in Example 1 (2.32 g, 4.2 mmol) was dissolved in methanol (30 ml). To the solution was added 10% palladium carbon (water content:50%, 0.93 g), and the mixture was subjected to catalytic hydrogenation reaction at room temperature for 16 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the titled compound (1.70 g, 4.1 mmol, Yield 97%).

Workup

  1. customthe mixture was subjected to catalytic hydrogenation reaction at room temperature for 16 hours
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f763e095e0904ba9b11afaa7474763be
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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