HCID 18539135, compound → HCID 18538613, compound

HRID 412930Notes

Reaction equation

HRID 412930 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18](=[O:42])[N:19]([CH2:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][CH:32]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:31][CH2:30]2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[C].[Pd]>[CH2:35]([CH:32]1[CH2:31][CH2:30][N:29]([CH2:28][CH2:27][CH2:26][N:19]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:18]([NH:17][CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[O:42])[CH2:34][CH2:33]1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 1

HCID 18539135HCID 18539135, compound

Product 1

HCID 18538613HCID 18538613, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The compound obtained in Example 12 (5.50 g, 9.7 mmol) was dissolved in methanol (60 ml). To the solution was added 10% palladium carbon (water content:50%, 2.2 g), and the mixture was subjected to catalytic hydrogenation reaction at room temperature for 16 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the titled compound (4.11 g, 9.5 mmol, Yield 98%).

Workup

  1. customthe mixture was subjected to catalytic hydrogenation reaction at room temperature for 16 hours
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1d653518b1d24b2da840c55f3e4151d3
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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