HCID 105162, compound → HCID 10199679, compound

HRID 412994Notes

Reaction equation

HRID 412994 reaction equation
CN1C2[C:5](=[CH:6]C(S(C3C=CC=CC=3)(=O)=O)=CC=2)[C:4](CCN)=[CH:3]1.[CH3:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([S:33]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)(=[O:35])=[O:34])=[CH:30][CH:31]=2)[C:26]([CH2:42][CH2:43][NH:44]C)=[C:25]1[CH3:46].CN1C2C(=CC(S(C3C=CC=CC=3)(=O)=O)=CC=2)C(CCN)=C1C.FC1C=C(S(C2C=C3C(=CC=2)N(C)C(C)=C3CCN)(=O)=O)C=C(F)C=1.FC1C=C(S(C2C=C3C(=CC=2)N(C)C(C)=C3CCNC)(=O)=O)C=C(F)C=1.CC1NC2C(C=1CCN)=CC(S(C1C3C(=CC=CC=3)C=CC=1)(=O)=O)=CC=2.[11CH4].[13NH3].[15OH2].[18FH]>>[CH3:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([S:33]([C:36]3[C:41]4[C:40](=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH:39]=[CH:38][CH:37]=3)(=[O:35])=[O:34])=[CH:30][CH:31]=2)[C:26]([CH2:42][CH2:43][NH2:44])=[C:25]1[CH3:46]

Participants

11

Reactant 10

HCID 105162HCID 105162, compoundHCID 11478914333-33-6HCID 119432Ammonia-13NHCID 6918691HCID 6918691, compoundHCID 9902622HCID 9902622, compoundHCID 9923494HCID 9923494, compoundHCID 99666322-[1-methyl-5-(phenylsulfonyl)-1H-indol-3-yl]ethanamineHCID 10129877Water O 15HCID 10133372HCID 10133372, compoundHCID 10177681HCID 10177681, compound

Product 1

HCID 10199679HCID 10199679, compound

Procedure

The compounds of formula I also can include isotopic labels. For example the compounds 2-[1-methyl-5-(phenylsulfonyl)-1H-indol-3-yl]ethanamine; 2-[1,2-dimethyl-5-(phenylsulfonyl)-1H-indol-3-yl]-N-methylethanamine; 2-[1,2-dimethyl-5-(phenylsulfonyl)-1H-indol-3-yl]ethanamine; 2-{5-[(3,5-difluorophenyl)sulfonyl]-1,2-dimethyl-1H-indol-3-yl}ethanamine; 2-{5-[(3,5-difluorophenyl)sulfonyl]-1,2-dimethyl-1H-indol-3-yl}-N-methylethanamine; 2-[2-methyl-5-(1-naphthylsulfonyl)-1H-indol-3-yl]ethanamine; and pharmaceutically acceptable salts thereof may contain an isotopic label such as at least one atom selected from Carbon-11, Nitrogen-13, Oxygen-15, and Fluorine-18. Isotopically labeled compounds may be used in positron emission tomography.

Sources & evidence

ORD record
ord-d8b2dfdd32ed4db59c92656af18bcf5a
Source dataset
uspto-grants-2003_05
Patent number
US06565829B2

Reaction notes

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