2-[2-(4-Fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl ester → 1-[2-(4-Fluorophenyl)acetyl]-pyrazolidin-4-one

HRID 413039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 413039
C(OC([N:11]1[CH2:15][C:14](=[O:16])[CH2:13][N:12]1[C:17](=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)=O)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][C:17]([N:12]2[CH2:13][C:14](=[O:16])[CH2:15][NH:11]2)=[O:26])=[CH:20][CH:21]=1

Komponenten

5

Edukt 2

HCID 129701552-[2-(4-Fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 129701591-[2-(4-Fluorophenyl)acetyl]-pyrazolidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-[2-(4-fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl ester, 4, (1 g, 4.5 mmol) in methanol (30 mL) is added Pd/C (100 mg). A balloon filled with hydrogen gas is placed over the flask and the mixture stirred for 3 hours. The solution is filtered to remove the catalyst and concentrated in vacuo to afford 0.8 g of the desired product as a yellow oil which is used without further purification.

Aufarbeitung

  1. filtrationThe solution is filtered
  2. customto remove the catalyst
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b2f435ce028c425899eeb7daf49b5782
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06566357B1

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