HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18523235, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-chloro-7,8-difluoroquinoline-3-carboxylate | HCID 18523305 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18523235 | HCID 18523235 | 92% |
Reaction Steps
A solution of 21.9 g of ethyl 4-chloro-7,8-difluoroquinoline-3-carboxylate in 7300 cm3 of ethanol in the presence of 8.8 g of triethylamine and 2.2 g of 5% palladium on carbon was hydrogenated at atmospheric pressure for 1 hour. The solid residue obtained was recrystallized from 300 cm3 of hexane. 17.6 g of ethyl 7,8-difluoroquinoline-3-carboxylate was obtained in the form of white crystals, which melted at 118° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566362B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-83559f6b461d4213881f68661e31a147 |
| Source note | uspto-grants-2003_05 |