HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413051Generated: October 31, 2026
Phosphorus oxychloride → Ethyl 4-chloro-7,8-difluoroquinoline-3-carboxylate
https://huagongshe.com/reaction/413051
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 70026123 | HCID 70026123 | — |
| Product | Ethyl 4-chloro-7,8-difluoroquinoline-3-carboxylate | HCID 18523305 | 97.9% |
Reaction Steps
A suspension of 26 g of ethyl 7,8-difluoro-4-oxoquinoline-3-carboxylate in 212 g of phosphorus oxychloride was heated at 95° C. for 4 hours, with stirring. After treatment, 27.3 g of ethyl 4-chloro-7,8-difluoroquinoline-3-carboxylate was obtained in the form of a white solid, which melted at 114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06566362B2 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-b49c741792bc489aa8792dc3afe406bf |
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| Source note | uspto-grants-2003_05 |
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