Acetic Acid → HCID 18523349, compound

Participants

Reaction Conditions

Reaction Steps

0.86 cm3 of 1 N aqueous potassium hydroxide was added, with stirring, to a suspension of 0.39 g of ethyl 7-fluoro-8-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidin-1-yl]-4-methyl-1-oxo-1,4-dihydrobenzo[f][1,7]naphthyridine-2-carboxylate in 4.5 cm3 of ethanol and 3.5 cm3 of water. The mixture was heated at about 80° C. for 3 hours, and then after cooling, 20 cm3 of water were added and then the medium was acidified with 0.05 cm3 of acetic acid. The precipitate was filtered off, dewatered, washed with 2 cm3 of isopropanol and then washed twice with 2 cm3 of diisopropyl ether and dried. 0.25 g of 7-fluoro-8-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidin-1-yl]-4-methyl-1-oxo-1,4-dihydrobenzo[f][1,7]naphthyridine-2-carboxylic acid was obtained in the form of a yellow solid, which melted above 260° C.

Provenance & Evidence