Chlorosulfonic acid → 4-Ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride

HRID 413076Notes

Reaction equation

HRID 413076 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:21])[N:18]=[C:19]([CH3:20])[N:12]2[N:11]=1)[CH3:2].[Cl:22][S:23](O)(=[O:25])=[O:24]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:23]([Cl:22])(=[O:25])=[O:24])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:21])[N:18]=[C:19]([CH3:20])[N:12]2[N:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 1354437382-(2-ethoxyphenyl)-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Product 1

HCID 1358567774-Ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride

Procedure

7.25 g (25.5 mmol) of 2-(2-ethoxyphenyl)-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one are initially charged, and 26.74 g (0.23 mol) of chlorosulphonic acid are added with ice-cooling,. The mixture is stirred at room temperature overnight and poured into ice-water, and the crystals are filtered off with suction and dried in a vacuum desiccator.

Workup

  1. temperaturecooling
  2. filtrationthe crystals are filtered off with suction
  3. customdried in a vacuum desiccator

Sources & evidence

ORD record
ord-2ca58206fdb743289bad24e9593f3543
Source dataset
uspto-grants-2003_05
Patent number
US06566360B1

Reaction notes

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