Chlorosulfonic acid → HCID 135856755, compound

HRID 413079Notes

Reaction equation

HRID 413079 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C:12]1[NH:17][C:16](=[O:18])[C:15]2=[C:19]([CH3:25])[N:20]=[C:21]([CH2:22][CH2:23][CH3:24])[N:14]2[N:13]=1)[CH3:2].[Cl:26][S:27](O)(=[O:29])=[O:28]>>[CH2:1]([O:3][C:4]1[C:5]([C:12]2[NH:17][C:16](=[O:18])[C:15]3=[C:19]([CH3:25])[N:20]=[C:21]([CH2:22][CH2:23][CH3:24])[N:14]3[N:13]=2)=[CH:6][C:7]([S:27]([Cl:26])(=[O:29])=[O:28])=[C:8]([O:10][CH3:11])[CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 135856735HCID 135856735, compound

Product 1

HCID 135856755HCID 135856755, compound

Procedure

At 0° C., 0.31 g (0.9 mmol) of 2-(2-ethoxy-4-methoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f]-[1,2,4]triazin-4-one are added slowly to 0.54 ml of chlorosulphonic acid. The reaction mixture is stirred at room temperature overnight and then poured into ice-water and extracted with dichloromethane. This gives 0.355 g (89%) of a colourless foam. Rf=0.50 (dichloromethane/methanol=20:1)

Workup

  1. extractionextracted with dichloromethane

Sources & evidence

ORD record
ord-6aa5747808e5424987daebe2cff4f7ab
Source dataset
uspto-grants-2003_05
Patent number
US06566360B1

Reaction notes

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