4-Hydroxypyrrolidine → HCID 135444735, compound

HRID 413084Notes

Reaction equation

HRID 413084 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH3:25])[N:22]=[C:23]([CH3:24])[N:16]2[N:15]=1)[CH3:2].[OH:26][CH:27]1[CH2:31][CH2:30][NH:29][CH2:28]1>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:29]2[CH2:30][CH2:31][CH:27]([OH:26])[CH2:28]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH3:25])[N:22]=[C:23]([CH3:24])[N:16]2[N:15]=1)[CH3:2]

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 1358567774-Ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride

Product 1

HCID 135444735HCID 135444735, compound

Procedure

By the same method, starting with 100 mg (0.261 mmol) of 4-ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and, 70 mg (0.784 mmol) of 3-hydroxypyrrolidine, 13 mg (11.1% of theory) of 2-[2-ethoxy-5-(3-hydroxy-pyrrolidine-1-sulphonyl)-phenyl]-5,7-dimethyl-3H-imidazo-[5,1-f][1,2]triazin-4-one are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-ac29debe4d2f44d2995501954f90e921
Source dataset
uspto-grants-2003_05
Patent number
US06566360B1

Reaction notes

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