HRID413086

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID612

Lactic acid

C3H6O3

结构：CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nn12

HCID135544141

未命名化合物

PRODUCTS

生成物

结构：CC(O)C(=O)O.CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nn12

HCID135856772

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

100 mg (0.211 mmol) of 2-[2-ethoxy-5-(4-methyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are suspended in 5 ml of ether and admixed with 20 mg of an 85% strength solution of lactic acid in water. The mixture is stirred at room temperature for 10 minutes and evaporated to dryness. The residue is titrated with ether and filtered off with suction. This gives 110 mg (92%) of 2-[2-ethoxy-5-(4-methyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one lactate.

WORKUP

后处理

customevaporated to dryness
filtrationfiltered off with suction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3246fdb08c5a43b2933cb7dd94c4a701
来源数据集: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06566360B1
来源说明: uspto-grants-2003_05

反应 SMILES

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH3:33])[N:28]=[C:29]([CH2:30][CH2:31][CH3:32])[N:22]2[N:21]=1)[CH3:2].[C:34]([OH:39])(=[O:38])[CH:35]([CH3:37])[OH:36]>CCOCC.O>[C:34]([OH:39])(=[O:38])[CH:35]([CH3:37])[OH:36].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:20]1[NH:25][C:24](=[O:26])[C:23]2=[C:27]([CH3:33])[N:28]=[C:29]([CH2:30][CH2:31][CH3:32])[N:22]2[N:21]=1)[CH3:2]